Introducing Hill Labs Capability to Perform Whole Genome Sequencing
With decades of experience in analytical services, we’re excited to share that Hill Labs is expanding its genomic capabilities. We can now offer Whole Genome Sequencing in-house, giving you a complete end-to-end service, from pathogen testing and detection right through to confirmation and now, sequencing.
Technology plays a pivotal role in ensuring that the food we eat is safe, nutritious, and free from harmful microorganisms. One of the most groundbreaking tools now available is Whole Genome Sequencing (WGS). By mapping the complete genetic makeup of foodborne pathogens and beneficial microbes, WGS is transforming the way we detect contamination, track outbreaks, and ensure the quality of our food. Here’s a closer look at how this technology is revolutionising food microbiology and beyond.
What Is Whole Genome Sequencing?
Whole Genome Sequencing (WGS) is a cutting-edge method to determine the entire genetic code of an organism. In food microbiology, this means sequencing the DNA of bacteria, viruses, and fungi that can contaminate food or play a role in fermentation. Unlike traditional methods that identify only a subset of genetic markers or species, WGS provides a comprehensive snapshot of an organism’s entire genetic blueprint. This allows scientists to explore not only the species but also uncover specific traits like pathogenicity, antimicrobial resistance, and genetic diversity.
WGS has a wide range of applications in microbiology and environmental analysis.
Key Applications of WGS
WGS is a game-changer when it comes to identifying and tracking foodborne illnesses. Pathogens like Salmonella, E. coli, and Listeria are responsible for numerous outbreaks each year, and tracing the source of contamination can be a complex task. WGS provides the precision needed to identify pathogens down to the strain level, enabling public health authorities to track the source of lineage(s) associated with outbreaks with greater accuracy than traditional methods.
One of the most powerful applications of WGS is tracing the path of contamination from farm to table. By comparing the genomes of microbes and pathogens found in different stages of food production—whether at the farm, processing plant, or retail outlet—scientists can map the more plausible source of contamination and genetic diversity of the microbial strains in the specific environment. This helps manufacturers, regulators, and farmers take immediate action to prevent further spread and improve food safety protocols.
Antimicrobial resistance (AMR) is a growing concern in both human health and food production. WGS plays a crucial role in identifying gene profiles in strains that are known to provide resistance against antibiotics and disinfectants in foodborne pathogens. This helps prevent the spread of resistant bacteria, which can be harder to treat and pose significant public health risks. In food production, monitoring AMR is essential for maintaining the efficacy of treatment and ensuring the safety of the food supply.
Fermentation is a delicate process in the production of many foods, from yogurt to cheese to sourdough bread. The balance of beneficial microbes is crucial for both the safety and quality of these products. WGS can help the food industry to better understand these microbial communities, optimizing fermentation processes and ensuring consistency in the final product. It can also help identify unwanted spoilage organisms that might affect food quality, ensuring that only the best microorganisms are present.
Technology Platform
Our Whole Genome Sequencing service is powered by Oxford Nanopore Technologies, a cutting-edge platform that delivers long-read sequencing with real-time data output. This technology allows us to sequence entire microbial genomes—including complex regions, plasmids, and structural variations—with high resolution and speed. Its flexibility enables rapid turnaround and comprehensive genetic insights from a wide range of sample types.
The introduction of Whole Genome Sequencing at Hill Labs marks a major step forward in our commitment to delivering industry-leading analytical services. By bringing this capability in-house, we’re offering our clients deeper insight into food safety, quality, and microbial dynamics. Whether you’re tracing contamination, monitoring antimicrobial resistance, or optimising fermentation processes, WGS provides endless opportunities for microbiological analysis. We’re proud to use this technology to help our clients achieve safer food systems and a healthier future for all.
